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Since genome annotation processing requires a lot of computation time and often takes a long time, it is widely practiced to execute this on an external server and obtain the result.
In addition, the genetic identification software used for genome annotation is developed to operate on Linux in many cases, it may not be possible to run on Windows.
Even in such a case, there is the merit of installing those software on the external Linux server and annotating it.
Because Mac OS X is based on Linux, many of those identification software work directly in the local environment of the Mac.
However, also in this case manual operation may be delayed when performing manual annotation in parallel, there is a merit of annotating on the external server even on Mac.
IMC has a function to create an annotation database on an external server, and it is easy to generate a search database on the server.